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Forensics
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Confident identification of unknown new psychoactive substances by a unique software workflow
Constant innovation in the creation of new psychoactive substances (NPS) means that new, potentially harmful substances are frequently entering the market, making it crucial to stay ahead in identification. The ability to confirm unknown chemical identities quickly and accurately is critical for law enforcement, security, and public safety. High-resolution tandem mass spectrometry (HR-MS/MS) and innovative data processing offer detailed insights into known drug targets and the detection of unexpected compounds. This study employs MetaboScape, a specialized software, for nontarget processing of HR-MS/MS data, facilitating the identification of NPS in seized powders. MetaboScape’s optimized workflow covers elemental formula calculation and structural confirmation, ensuring robust compound identification. The study showcases MetaboScape’s effectiveness in identifying Modafiendz, a fluorinated analog of the controlled substance modafinil, in a seized powder.
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Rapid, Chromatography-Free Quantitative Workflow of the Potent Sedative Xylazine by DART-MS Analysis
Xylazine is a synthetic compound that has escalated concern within United States health and law enforcement agencies due to its increased use as an adulterant in the illicit street drug fentanyl. Numbers of opioid overdoses continue to be significant and the detection of xylazine as an adulterant in illicit drugs is increasing each year. Thus, interest to be able to measure this drug rapidly and effectively in mixed lab samples is escalating. A technique utilizing a chromatography-free workflow by Direct Analysis in Real Time ionization coupled with mass spectrometry (DART-MS) offers simple, quick identification of xylazine. For this study, a mixture containing xylazine, fentanyl, and chlorpromazine spiked into drug-free urine was used to demonstrate the effectiveness of DART-MS. The linear responses of the drugs with respect to the QC samples and across a large detection range ensure that this chromatography-free workflow will be able to detect samples at referenced levels. The ability to conduct rapid analysis of such drugs allows for quicker and more confident treatment decisions to overdose victims, who may not fully respond to current overdose treatments.