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Generally used as flame retardants, Brominated Diphenyl Ethers (BDEs) have become chemicals of significant environmental concern. BDEs are persistent and highly lipophilic substances, similar to well-known environmental contaminants such as PCBs. Flame retardants highlight the need to develop risk assessments about chemicals meant to protect us and the effect of their exposure to humans and the environment. CIL first synthesized 13C-BDEs in the 1980s as part of the earliest PBDD / PBDF analytical program.